Methylprednisolone in the management of spinal cord injuries ncbi. Corticoides dans les traumatismes du systeme nerveux. The national acute spinal cord injury study nascis 2 and 3 trials are often cited as evidence that highdose methylprednisolone is an efficacious intervention in the management of acute spinal cord injury. This randomized clinical trial rct continues the work of the national acute spinal cord injury study nascis group in attempting to treat patients with acute. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of 41 columna. Pdf highdose methylprednisolone for acute closed spinal cord. Bolus dose of 30 mgkg of body weight over 15 minutes, followed by a 45minute pause, and then a 23hour continuous infusion of 5.
With certainty, only the most interesting data were reported. Methylprednisolone in the management of spinal cord. In nascis iii it is also likely that all possible comparisons between 0 and 8 hours were made 1 hour and 18 hours, 2 hours and 28 hours, 3 hours and 3 8 hours, and so on. Methylprednisolone a haute dose dans le traitement des. Nascis ii, 1990 was a multicenter, doubleblinded rct that randomized 487 patients with acute traumatic sci to three arms. The national acute spinal cord injury nascis is com posed of three multicentric.